Faculty of Life Sciences, University of Manchester, UK.
Acta Physiol (Oxf). 2011 Sep;203(1):127-37. doi: 10.1111/j.1748-1716.2010.02249.x. Epub 2011 Mar 1.
The extracellular calcium-sensing receptor (CaR) was first described in the parathyroid gland. Recent studies have shown that the CaR is also expressed in blood vessels, especially in the endothelial and adventitial layers but its physiological function is still not clear. However, an understanding of its possible role(s) in the vasculature (perivascular-neurones, heart and blood vessels) is important because of the use of synthetic positive allosteric CaR modulators in hyperparathyroidism and the potential importance of negative modulators in the treatment of osteoporosis. In this review, the effects of CaR activation and inhibition are detailed and the possible role of the CaR as both an amplifier and attenuator of myo-endothelial coupling in the vasculature is described.
细胞外钙敏感受体（CaR）最初在甲状旁腺中被描述。最近的研究表明，CaR 也在血管中表达，特别是在内皮和外膜层，但它的生理功能尚不清楚。然而，由于在甲状旁腺功能亢进症中使用合成的正变构 CaR 调节剂以及在骨质疏松症治疗中负调节剂的潜在重要性，了解其在血管（血管周围神经元、心脏和血管）中的可能作用非常重要。在这篇综述中，详细描述了 CaR 激活和抑制的作用，并描述了 CaR 作为血管中肌内皮偶联的放大器和衰减器的可能作用。
