Laboratory of Molecular Bacteriology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil.
Vaccine. 2011 Feb 4;29(7):1438-42. doi: 10.1016/j.vaccine.2010.12.045. Epub 2011 Jan 1.
Haemophilus influenzae type b vaccine was introduced into the Immunization Program of Brazil in 1999 and no study has evaluated the impact of Hib vaccination in H. influenzae carriage so far. In June 2010, Brazil introduced the 10-valent pneumococcal nontypeable H. influenzae (NTHi) conjugate vaccine (PHiD-CV). We investigated the prevalence of encapsulated H. influenzae and NTHi isolates in nasopharyngeal samples of 1192 children attending day-care centers in Goiânia, central Brazil. H. influenzae carriage rate was 32.1% and 38.4% of them carried β-lactamase TEM-1 gene. Serotype f (4.6%) was the most frequent encapsulated isolate, type b was recovered in only 0.7% and carriage rate of NTHi was 23.3%. Recurrent acute otitis media and NTHi were independently associated with colonization by β-lactamase producing H. influenzae. Changes in frequency of H. influenzae carriage isolates should be carefully monitored to assess the impact of the PHiD-CV on NTHi carriage in young children.
b 型流感嗜血杆菌疫苗于 1999 年被引入巴西免疫计划，但迄今为止，尚无研究评估 Hib 疫苗接种对流感嗜血杆菌携带的影响。2010 年 6 月，巴西引入了 10 价肺炎球菌结合型无荚膜流感嗜血杆菌（NTHi）疫苗（PHiD-CV）。我们调查了巴西戈亚尼亚日托中心 1192 名儿童鼻咽样本中包膜流感嗜血杆菌和 NTHi 分离株的流行情况。流感嗜血杆菌携带率为 32.1%，其中 38.4%携带β-内酰胺酶 TEM-1 基因。血清型 f（4.6%）是最常见的包膜分离株，b 型仅回收 0.7%，NTHi 的携带率为 23.3%。复发性急性中耳炎和 NTHi 与产β-内酰胺酶流感嗜血杆菌的定植独立相关。应仔细监测流感嗜血杆菌携带分离株的频率变化，以评估 PHiD-CV 对幼儿中 NTHi 携带的影响。
