Department of Medicine, Sohar Hospital, Muscat, Oman.
Arch Med Res. 2010 Nov;41(8):618-22. doi: 10.1016/j.arcmed.2010.11.006.
Acute coronary syndrome (ACS) is associated with many hereditary and acquired predisposing factors. It has been recently shown that inflammation may play a role in myocardial ischemia. Hence, the white blood cell (WBC) count provides a simple and inexpensive method for assessment of inflammatory status in patients with ACS. An elevated WBC count has been associated with cardiovascular risk, but which leukocyte subtype carries this risk is uncertain. The aim of this study was to investigate the utility of admission neutrophil/lymphocyte ratio (NLR) in predicting the likelihood of poor outcomes in patients with ACS.
A total of 300 consecutive patients admitted to the Internal Medicine Department, Sohar Hospital, Oman with the diagnosis of ACS from June 2008 to May 2009 were included in this study. Patients were divided into tertile groups according to the NLR. The primary end point was all-cause in-hospital mortality at the end of 30 days.
The mean age of patients included in this cohort was 61 years, with 63% of male patients. The mortality in the three groups based on NLR was 4, 10 and 19%, in the low-, middle- and high-risk groups, respectively (p <0.003; χ² test).
Admission NLR is clearly an independent predictor of all-cause mortality in patients with ACS.
急性冠状动脉综合征（ACS）与许多遗传和获得性易患因素有关。最近有研究表明，炎症可能在心肌缺血中起作用。因此，白细胞（WBC）计数为评估 ACS 患者的炎症状态提供了一种简单且经济的方法。白细胞计数升高与心血管风险相关，但哪种白细胞亚型具有这种风险尚不确定。本研究旨在探讨入院时中性粒细胞/淋巴细胞比值（NLR）在预测 ACS 患者不良预后中的作用。
本研究纳入了 2008 年 6 月至 2009 年 5 月期间在阿曼苏哈尔医院内科就诊并被诊断为 ACS 的 300 例连续患者。根据 NLR 将患者分为三分位组。主要终点是 30 天内全因院内死亡率。
该队列患者的平均年龄为 61 岁，其中 63%为男性。根据 NLR，三组的死亡率分别为 4%、10%和 19%，分别为低风险、中风险和高风险组（p<0.003；χ²检验）。
入院时 NLR 是 ACS 患者全因死亡率的独立预测因子。
