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6-(4-Methyl-phen-yl)-3-(3,4,5-trimethoxy-phen-yl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole.

作者信息

Du Hai-Tang, Du Hai-Jun, Zhou Weiyi

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Sep 30;64(Pt 10):o2040. doi: 10.1107/S1600536808030936.

DOI:10.1107/S1600536808030936
PMID:21201232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2959370/
Abstract

In the mol-ecule of the title compound, C(19)H(18)N(4)O(3)S, the central heterocylic ring system is oriented with respect to the trimethoxy-phenyl and 4-methyl-phenyl rings at dihedral angles of 1.1 (5) and 15.1 (5)°, respectively. The dihedral angle between the two benzene rings is 16.1 (4)°. In the crystal structure, mol-ecules are linked by inter-molecular C-H⋯O hydrogen bonds, and an intra-molecular C-H⋯N inter-action also occurs.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a672/2959370/b1ea16974393/e-64-o2040-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a672/2959370/4785969060ef/e-64-o2040-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a672/2959370/b1ea16974393/e-64-o2040-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a672/2959370/4785969060ef/e-64-o2040-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a672/2959370/b1ea16974393/e-64-o2040-fig2.jpg

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引用本文的文献

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本文引用的文献

1
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
Studies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues.3,6-二取代-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑及其二氢类似物的合成与药理活性研究
Eur J Med Chem. 2007 Jun;42(6):823-40. doi: 10.1016/j.ejmech.2006.12.010. Epub 2007 Jan 9.
3
Synthesis and antimicrobial activities of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines carrying thioalkyl and sulphonyl phenoxy moieties.
一些带有硫代烷基和磺酰基苯氧基部分的新型1,2,4-三唑并[3,4-b]-1,3,4-噻二唑及1,2,4-三唑并[3,4-b]-1,3,4-噻二嗪的合成与抗菌活性
Eur J Med Chem. 2007 Apr;42(4):521-9. doi: 10.1016/j.ejmech.2006.10.010. Epub 2006 Dec 6.