Herrmann A, Jauch K W, Günther B, Schildberg F W
Chir. Klinik, Ludwig-Maximilians-Universität, München.
Infusionstherapie. 1990 Aug;17(4):185-90; 193-6.
Medium chain triglycerides (MCT) may be particularly well-suited for rapid energy supply in postoperative patients because of their rapid availability. We compared the elimination and metabolization of 10% and 20% MCT/LCT-containing infusions (Lipofundin MCT) in 29 non diabetic patients to 10% and 20% LCT-containing infusions during a course of a 7-day TPN. The speed of the provision of triglycerides does not depend on the composition of the fat emulsions. The maximum TG-levels after fat infusion over 12 hours remained under 3 mmol/l. In the MCT/LCT 20% group we found the lowest half-life of the triglycerides with 77 min at the 1st, 133 min at the 4th, and 72 min at the 7th postoperative day. In addition this group showed persistent low half-lives for free fatty acids: 85 min on day 1, 42 min on day 4, and 39 min on day 7. A comparable liberation of fatty acids in corresponding half-lives could be observed in the LCT-groups only after a course of 7 days: 0.86 resp. 0.69 mmol/l (LCT 10% resp. 20%) on day 1, 1.25 resp. 1.26 mmol/l on day 4, and 1.31 resp. 1.97 mmol/l on day 7. The results of the MCT/LCT 20%-group may be due to a quicker metabolization of these emulsions with favourable availability.
中链甘油三酯（MCT）因其快速可用性，可能特别适合为术后患者快速提供能量。我们在29例非糖尿病患者的7天全胃肠外营养（TPN）过程中，将含10%和20% MCT/LCT的输注液（Lipofundin MCT）的清除和代谢情况与含10%和20%长链甘油三酯（LCT）的输注液进行了比较。甘油三酯的供应速度并不取决于脂肪乳剂的成分。12小时脂肪输注后的最大甘油三酯水平保持在3 mmol/l以下。在MCT/LCT 20%组中，我们发现甘油三酯的半衰期最短，术后第1天为77分钟，第4天为133分钟，第7天为72分钟。此外，该组游离脂肪酸的半衰期持续较低：第1天为85分钟，第4天为42分钟，第7天为39分钟。只有在7天疗程后，LCT组才能观察到相应半衰期内脂肪酸的类似释放情况：第1天分别为0.86和0.69 mmol/l（LCT 10%和20%），第4天分别为1.25和1.26 mmol/l，第7天分别为1.31和1.97 mmol/l。MCT/LCT 20%组的结果可能是由于这些乳剂代谢更快且可用性良好。
