Mai Anna, Khan Gul S, Clark George R, Barker David
Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Acta Crystallogr Sect E Struct Rep Online. 2008 May 3;64(Pt 6):o978-9. doi: 10.1107/S1600536808009410.
The title compound, C(18)H(21)N(3)O(5), was prepared by the reaction of 3-benzamido-5-nitro-benzyl methane-sulfonate with diethano-lamine and is an inter-mediate in the synthesis of DNA minor-groove-binding polybenzamide agents capable of being conjugated to additional biologically active species. The asymmetric unit contains two independent mol-ecules, which differ only in the orientations of the hydroxy-ethyl groups. In the crystal structure, inter-molecular N-H⋯O and O-H⋯O hydrogen bonds link mol-ecules into one-dimensional chains.
标题化合物C(18)H(21)N(3)O(5)由3-苯甲酰胺基-5-硝基苄基甲磺酸酯与二乙醇胺反应制备而成，是一种可与其他生物活性物质偶联的DNA小沟结合型聚苯甲酰胺类药物合成中的中间体。不对称单元包含两个独立分子，它们仅在羟乙基的取向上有所不同。在晶体结构中，分子间的N-H⋯O和O-H⋯O氢键将分子连接成一维链。
