Department of Neurology Radiology, MR Unit Pediatric Rehabilitation Psychology, The Children's Memorial Health Institute, Warsaw, Poland.
Epilepsia. 2011 Jan;52(1):22-7. doi: 10.1111/j.1528-1167.2010.02892.x. Epub 2011 Jan 4.
The aim of the study was to reveal the relationships between the tuber count of the brain found in patients with tuberous sclerosis complex (TSC) and their cognitive outcome.
A single-center, retrospective analysis was performed of patients with documented TSC seen from 1988 to 2010 at the Children's Memorial Health Institute, Warsaw, Poland.
Sixty-two patients were analyzed, and there was a significant correlation between younger age at the first seizure and developmental delay. The patients who did not develop seizures had normal development, despite some presenting with higher tuber load than those with seizures. There was a statistically significant negative correlation between the number of tubers within the right temporal lobe and cognition.
Our findings confirm our hypothesis that the cognitive outcome in TSC is more dependent on the age of the seizure onset rather than on the tuber count.
本研究旨在揭示结节性硬化症（TSC）患者脑内结节数量与其认知结果之间的关系。
对 1988 年至 2010 年期间在波兰华沙儿童纪念卫生研究所就诊的 TSC 患者进行了单中心回顾性分析。
对 62 例患者进行了分析，首次癫痫发作时年龄较小与发育迟缓显著相关。未发生癫痫的患者发育正常，尽管一些患者的结节负荷高于发生癫痫的患者。右侧颞叶内结节数量与认知功能呈显著负相关。
我们的研究结果证实了我们的假设，即 TSC 的认知结果更多地取决于癫痫发作的年龄，而不是结节数量。
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