结节性硬化症的手术结果：一项多中心调查。

Surgical outcome in tuberous sclerosis complex: a multicenter survey.

作者信息

Madhavan Deepak, Schaffer Sarah, Yankovsky Alexei, Arzimanoglou Alexis, Renaldo Florence, Zaroff Charles M, LaJoie Josiane, Weiner Howard L, Andermann Eva, Franz David N, Leonard Jennifer, Connolly Mary, Cascino Greg D, Devinsky Orrin

机构信息

Comprehensive Epilepsy Center, Department of Neurology, NYU Medical Center, 403 East 34th Street, New York, NY 10016, U.S.A.

出版信息

Epilepsia. 2007 Aug;48(8):1625-8. doi: 10.1111/j.1528-1167.2007.01112.x. Epub 2007 May 1.

DOI:10.1111/j.1528-1167.2007.01112.x

PMID:17484758

Abstract

Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.

摘要

对70例因癫痫缓解而接受手术的结节性硬化症（TSC）患者进行多中心回顾性分析发现，癫痫发作起始时年龄较小、有/曾有婴儿痉挛病史、发作间期病灶情况（双侧与单侧）以及术后无残留主要结节，与术后较差的预后显著相关（p < 0.01）。发作期多灶性、智力发育迟缓以及脑电图（EEG）和磁共振成像（MRI）数据不一致对预后呈负向趋势，但不显著。