Min W K, Kim Y B, Lee K M
Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.
Korean J Ophthalmol. 1990 Jun;4(1):12-5. doi: 10.3341/kjo.1990.4.1.12.
Tissue plasminogen activator(tPA) is a fibrin-specific fibrinolytic agent that has recently been shown to be effective in accelerating the clearance of hyphema. Intravitreal injection of tPA can promote rapid lysis of experimental intravitreal fibrin clots. The purpose of this study was to investigate the efficacy of intravitreal tPA injection for the treatment of vitreous hemorrhage in normal phakic non-vitrectomized rabbit eyes. Vitreous hemorrhages were produced by intravitreal injections of 0.05 ml of autologous whole blood in 25 rabbit eyes with intact vitreous. The injection of 25 or 100 micrograms of tPA in 15 eyes resulted in the clearance of vitreous hemorrhage in 99 +/- 19 or 34 +/- 6.5 days, respectively. This was significantly faster than in the control eyes in which the clearance was not seen until 131 +/- 17 days later. No tractional retinal detachment was observed.
组织型纤溶酶原激活剂（tPA）是一种纤维蛋白特异性纤溶药物，最近已证明其在加速前房积血清除方面有效。玻璃体内注射tPA可促进实验性玻璃体内纤维蛋白凝块的快速溶解。本研究的目的是探讨在正常有晶状体未行玻璃体切割术的兔眼中玻璃体内注射tPA治疗玻璃体积血的疗效。通过向25只玻璃体完整的兔眼玻璃体内注射0.05 ml自体全血产生玻璃体积血。向15只眼中注射25微克或100微克tPA后，玻璃体积血分别在99±19天或34±6.5天清除。这明显快于对照眼，对照眼中直到131±17天后才出现积血清除。未观察到牵拉性视网膜脱离。
