Rylands Angela J, McKie Shane, Elliott Rebecca, Deakin J F William, Tarrier Nicholas
Department of Clinical Psychology, School of Psychological Sciences, University of Manchester, Manchester, United Kingdom.
J Nerv Ment Dis. 2011 Jan;199(1):25-9. doi: 10.1097/NMD.0b013e3182043b87.
Chronic exposure to adverse interpersonal environment in schizophrenia is associated with vulnerability to relapse. The construct of expressed emotion (EE) measures the quality of interpersonal environment, of which criticism is a main component. To use functional magnetic resonance imaging and to investigate the neural basis of vulnerability of schizophrenic patients to EE, the effects of critical comments on brain mechanisms in 11 patients with schizophrenia were examined, comparing evoked responses to familiar (key relative) and unfamiliar (matched stranger) critical and neutral commentary. High EE stimuli evoked enhanced activation of brain regions concerned with the processing of aversive social information. Activations in the right BA44, rostral anterior cingulate, middle superior frontal gyrus, bilateral middle frontal gyrus, left temporal pole, left inferior frontal gyrus, and left insula were significantly modulated to familiar criticism. Such a pattern of neural response may represent a putative neural network responsible for mediating High EE in schizophrenia.
精神分裂症患者长期暴露于不良人际环境中与复发易感性相关。情感表达（EE）结构用于衡量人际环境质量，其中批评是主要组成部分。为了使用功能磁共振成像并研究精神分裂症患者对EE易感性的神经基础，我们检测了11例精神分裂症患者对批评性评论的脑机制影响，比较了对熟悉（主要亲属）和不熟悉（匹配陌生人）的批评性及中性评论的诱发反应。高EE刺激引发了与厌恶社会信息处理相关脑区的激活增强。右侧BA44、喙前扣带回、额上回中部、双侧额中回、左侧颞极、左侧额下回和左侧岛叶的激活对熟悉的批评有显著调节作用。这种神经反应模式可能代表了一个假定的神经网络，负责介导精神分裂症中的高EE。
