可卡因类似物偶联到缺陷型腺病毒：一种针对成瘾性药物的高滴度免疫的疫苗策略。
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs.
机构信息
Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA.
出版信息
Mol Ther. 2011 Mar;19(3):612-9. doi: 10.1038/mt.2010.280. Epub 2011 Jan 4.
Abstract
Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction. Leveraging the knowledge that E1(-)E3(-) adenovirus (Ad) gene transfer vectors are potent immunogens, we have developed a novel vaccine platform for addictive drugs by covalently linking a cocaine analog to the capsid proteins of noninfectious, disrupted Ad vector. The Ad-based anticocaine vaccine evokes high-titer anticocaine antibodies in mice sufficient to completely reverse, on a persistent basis, the hyperlocomotor activity induced by intravenous administration of cocaine.
摘要
基于抗可卡因抗体可以阻止吸入的可卡因到达大脑中的靶受体这一概念，一种有效的抗可卡因疫苗可能有助于逆转可卡因成瘾。利用 E1(-)E3(-)腺病毒（Ad）基因转移载体是有效的免疫原这一知识，我们通过将可卡因类似物与无感染性、破坏的 Ad 载体的衣壳蛋白共价连接，开发了一种用于成瘾性药物的新型疫苗平台。基于 Ad 的抗可卡因疫苗在小鼠中引发高滴度的抗可卡因抗体，足以持续完全逆转静脉给予可卡因引起的过度活动。
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