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Targeting IGF-1R: throwing out the baby with the bathwater?

作者信息

Basu B, Olmos D, de Bono J S

出版信息

Br J Cancer. 2011 Jan 4;104(1):1-3. doi: 10.1038/sj.bjc.6606023.

Abstract
摘要

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本文引用的文献

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Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab.
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Targeting insulin-like growth factor signaling: rational combination strategies.
Mol Cancer Ther. 2010 Sep;9(9):2447-9. doi: 10.1158/1535-7163.MCT-10-0719. Epub 2010 Aug 31.
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Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition.
Clin Cancer Res. 2010 Sep 15;16(18):4654-65. doi: 10.1158/1078-0432.CCR-10-0089. Epub 2010 Jul 29.
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Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10791-8. doi: 10.1073/pnas.0914076107. Epub 2010 May 10.
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Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma.
N Engl J Med. 2009 Sep 3;361(10):947-57. doi: 10.1056/NEJMoa0810699. Epub 2009 Aug 19.

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