Iwasaki S, Nakagawa H, Kichikawa K, Fukusumi A, Watabe Y, Kitamura K, Otsuji H, Ohishi H, Uchida H
Department of Radiology, Nara Medical University, Japan.
AJNR Am J Neuroradiol. 1990 Sep-Oct;11(5):1029-34.
A review of MR and CT images in five patients, 8 months to 22 years old, diagnosed as having tuberous sclerosis, revealed linear abnormalities in the cerebral white matter. A linear abnormality connecting a subependymal nodule to a subcortical lesion was shown in two patients as an area of hypointensity on T1-weighted MR images and as an area of hyperintensity on T2-weighted images. These appeared as faintly high-density areas on CT images. Seventeen linear abnormalities extending from the ventricle to the cortex with a subependymal nodule or subcortical lesion on each end were visible in all five patients as areas of hyperintensity on the T2-weighted images. On the T1-weighted images, only nine hypointense lines were noted. CT scans did not show these latter lines. Linear abnormalities in cerebral white matter are suggestive of lesions of demyelination, dysmyelination, hypomyelination, or lines of migration disorder. MR imaging, especially T2-weighted, is particularly sensitive in detecting these abnormalities.
对5例年龄在8个月至22岁、被诊断为结节性硬化症的患者的磁共振成像（MR）和计算机断层扫描（CT）图像进行回顾，发现脑白质存在线性异常。在两名患者中，连接室管膜下结节与皮质下病变的线性异常在T1加权MR图像上表现为低信号区，在T2加权图像上表现为高信号区。这些在CT图像上表现为低密度区。在所有5例患者中，均可见17条从脑室延伸至皮质的线性异常，两端各有一个室管膜下结节或皮质下病变，在T2加权图像上表现为高信号区。在T1加权图像上，仅发现9条低信号线。CT扫描未显示这些低信号线。脑白质中的线性异常提示脱髓鞘、髓鞘形成异常、髓鞘发育不全或迁移障碍线等病变。磁共振成像，尤其是T2加权成像，在检测这些异常方面特别敏感。
