Chaudhary K P
Department of Ophthalmology, I. G. Medical College, Shimla, India.
Ann Ophthalmol. 1990 Aug;22(8):314-8.
The steroids in vernal keratoconjunctivitis (VKC) are not always effective and may result in glaucoma. Cromolyn sodium inhibits degranulation from mast cells, thus preventing release of prostaglandins and the mediators of inflammation when used topically. Aspirin, which blocks the production of inflammation-producing prostaglandins in mast cells released in VKC, especially prostaglandin D2, was used orally in 11 patients with intractable VKC of mixed type with limbal predominance. The chi 2 test of combined therapy showed a significant improvement in itching, lacrimation, and limbal edema (P less than .005) and improved photophobia, palpebral lesions, and corneal staining (P less than .02) at six weeks.
春季角结膜炎（VKC）中的类固醇药物并非总是有效，且可能导致青光眼。色甘酸钠可抑制肥大细胞脱颗粒，因此局部使用时可防止前列腺素及炎症介质的释放。阿司匹林可阻断VKC中释放的肥大细胞产生炎症性前列腺素，尤其是前列腺素D2，11例以角膜缘为主的混合型顽固性VKC患者口服了阿司匹林。联合治疗的卡方检验显示，六周时瘙痒、流泪和角膜缘水肿有显著改善（P<0.005），畏光、睑裂部病变和角膜染色也有所改善（P<0.02）。
