病理性近视脉络膜视网膜萎缩边缘脉络膜新生血管的光动力疗法用维替泊芬的长期研究。

A long-term study of photodynamic therapy with verteporfin for choroidal neovascularization at the edge of chorioretinal atrophy in pathologic myopia.

机构信息

Department of Ophthalmology, Melegnano Hospital, Milan, Italy.

出版信息

Ophthalmologica. 2011;225(3):161-8. doi: 10.1159/000322362. Epub 2011 Jan 5.

DOI:10.1159/000322362

PMID:21212705

Abstract

PURPOSE

To evaluate the effects of verteporfin photodynamic therapy (PDT) on choroidal neovascularization (CNV) at the edge of chorioretinal atrophy in eyes with pathologic myopia.

PROCEDURES

Twenty eyes of 20 consecutive patients were treated according to Verteporfin in Photodynamic Therapy criteria. The patients were divided into 3 groups based on CNV location and were followed up with clinical and fluorescein angiographic examinations to evaluate visual acuity (VA) changes and number of treatments.

RESULTS

The mean follow-up was 35 months. In group 1 (n = 8; subfoveal CNV), VA declined from 20/73 (0.56 ± 0.26 logMAR) to 20/115 (0.76 ± 0.30 logMAR; p = 0.192). In group 2 (n = 6; juxtafoveal CNV), VA improved from 20/69 (0.54 ± 0.25 logMAR) to 20/46 (0.36 ± 0.16 logMAR; p = 0.176). In group 3 (n = 6; extrafoveal CNV), VA worsened from 20/50 (0.40 ± 0.21 logMAR) to 20/91 (0.66 ± 0.49 logMAR; p = 0.292).

CONCLUSIONS

PDT showed inhibitory effects on myopic CNV arising at the edge of chorioretinal atrophy, especially in young adult myopic eyes with juxtafoveal neovascular membranes.

摘要

目的

评估维替泊芬光动力疗法（PDT）对病理性近视脉络膜视网膜萎缩边缘的脉络膜新生血管（CNV）的疗效。

方法

根据维替泊芬光动力疗法标准，对 20 例（20 只眼）连续患者的眼睛进行了 20 只眼的治疗。根据 CNV 位置将患者分为 3 组，并进行临床和荧光素血管造影检查随访，以评估视力（VA）变化和治疗次数。

结果

平均随访时间为 35 个月。在第 1 组（n = 8；中心凹下 CNV）中，VA 从 20/73（0.56 ± 0.26 logMAR）下降至 20/115（0.76 ± 0.30 logMAR；p = 0.192）。在第 2 组（n = 6；中心凹旁 CNV）中，VA 从 20/69（0.54 ± 0.25 logMAR）提高至 20/46（0.36 ± 0.16 logMAR；p = 0.176）。在第 3 组（n = 6；旁中心凹外 CNV）中，VA 从 20/50（0.40 ± 0.21 logMAR）恶化至 20/91（0.66 ± 0.49 logMAR；p = 0.292）。