Division of Rheumatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Clin Rheumatol. 2011 Mar;30(3):415-8. doi: 10.1007/s10067-010-1652-7. Epub 2011 Jan 7.
Elevated levels of complement components, C3 and C4, are often seen in inflammatory diseases. They are generally not thought to be responsible for organ injury but simply reflect stimulation of the immune system. Extremely high elevations of these components are rarely seen. Such values are usually reported in patients with hematopoietic malignancies. We report here a case of C3 elevation to 9.22 g/L (5 times the upper limit of normal) and C4 elevation to 2.48 g/L (6 times the upper limit of normal). To our knowledge, no prior elevations of this magnitude have been reported previously from our institution or in the published medical literature (+/- MEDLINE search, using keywords hypercomplementemia, C3, C4, and lymphoplasmacytic lymphoma). In this case, there appeared to be no adverse end-organ damage from the excessive complement components or their activation.
补体成分 C3 和 C4 水平升高常见于炎症性疾病。一般认为它们不会导致器官损伤，而只是反映免疫系统受到刺激。这些成分的极高水平很少见。此类值通常在造血系统恶性肿瘤患者中报告。我们在此报告一例 C3 升高至 9.22g/L（正常值上限的 5 倍）和 C4 升高至 2.48g/L（正常值上限的 6 倍）。据我们所知，此前我们机构或已发表的医学文献中均未报告过如此大幅度的升高（+/- 使用关键词 hypercomplementemia、C3、C4 和 lymphoplasmacytic lymphoma 进行 MEDLINE 搜索）。在本例中，似乎没有来自过量补体成分或其激活的不良终末器官损伤。
