Jie Sun, Yu Chen, Xiaohu Lu, Yanning Qian, Zhengnian Ding, Xiaoyang Tang
Department of Anesthesiology, Jiangsu Province Hospital, Nanjing Medical University, Nanjing 210029, PR China.
J Heart Valve Dis. 2010 Nov;19(6):786-8.
The intraoperative use of amiodarone in patients with atrial fibrillation (AF) undergoing valvular heart surgery was unclear. Hence, a randomized clinical trial was designed to evaluate the effect of amiodarone on cardiac recovery and rhythm following mitral valve surgery.
A total of 120 elective mitral valve replacement patients with AF received either amiodarone (5 mg/kg) or the same volume of saline during cardiopulmonary bypass (CPB), in a randomized manner. Cardiac recovery was assessed by the heart auto re-beat ratio, the time from reperfusion to heart beat, the post-reperfusion rhythm, pacemaker use, and vasoactive drug use.
A higher heart auto re-beat ratio, higher sinus rhythm ratio, lower electric defibrillation ratio and less dopamine usage were found in the amiodarone treatment group. However, the proportion of temporary pacemaker use was lower in the control group.
Amiodarone had a good effect on cardiac recovery and the rhythm of AF patients after CPB.
Zotero 插件