Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA.
Cell. 2011 Jan 7;144(1):11-2. doi: 10.1016/j.cell.2010.12.023.
In this issue, Durieux et al. (2011) describe a tissue-specific signal, originating from mitochondria, that acts cell non-autonomously to regulate life span in the nematode, C. elegans. This new finding provides a first step toward resolving the relative contributions of mitochondrial free radical damage and signaling mechanisms in aging.
在本期中，Durieux 等人（2011 年）描述了一种组织特异性信号，该信号源自线粒体，以非自主细胞的方式调节线虫 C. elegans 的寿命。这一新发现为解决线粒体自由基损伤和衰老信号机制的相对贡献提供了第一步。
