粘菌素耐药鲍曼不动杆菌毒力和体内适应性受损。
Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.
机构信息
Servicio de Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Seville, Sevilla, Spain.
出版信息
J Infect Dis. 2011 Feb 15;203(4):545-8. doi: 10.1093/infdis/jiq086. Epub 2011 Jan 7.
Abstract
Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings.
摘要
鲍曼不动杆菌（美国模式培养物集存库菌株 19606）在体外对黏菌素耐药性的发展过程中会获得 pmrB 基因突变。耐黏菌素菌株对黏菌素的亲和力较低，体内适应性（竞争指数，.016）降低，毒力降低，无论是在死亡率（0%致死剂量，6.9 与 4.9 对数集落形成单位）还是在腹膜炎的小鼠模型中的存活率方面都是如此。这些结果可能解释了在临床环境中鲍曼不动杆菌对黏菌素耐药性的低发生率和传播率。
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