Department of Pediatrics, College of Medicine, University of South Florida, Pediatrics Epidemiology Center, Tampa, FL 33612, USA.
Diabetes Metab Res Rev. 2011 Jan;27(1):3-13. doi: 10.1002/dmrr.1141. Epub 2010 Oct 29.
The incidence of type 1 diabetes is increasing and this may double the burden of disease in our youngest by 2020. The recent increase in incidence is mostly happening in the very young and those with moderate genetic susceptibility. Many environmental factors have been implicated, but no major determinants have been clearly identified, and the mechanisms of involvement remain elusive. This review summarizes current research efforts directed at understanding the possible reasons for this increase, including the role of viruses, gut microbiota, early life feeding patterns, perinatal factors and childhood growth patterns. It also provides a road map for future research directions.
1 型糖尿病的发病率正在上升，到 2020 年，这可能使我们最年轻的人群的疾病负担增加一倍。最近发病率的上升主要发生在非常年幼的人群和那些具有中度遗传易感性的人群中。许多环境因素都被牵涉其中，但没有明确确定主要决定因素，其涉及的机制仍然难以捉摸。这篇综述总结了目前旨在了解这种增加可能原因的研究工作，包括病毒、肠道微生物群、生命早期喂养模式、围产期因素和儿童生长模式的作用。它还为未来的研究方向提供了路线图。
