Ly T M, Müller H E
Staatliches Medizinaluntersuchungsamt Braunschweig, Federal Republic of Germany.
J Med Microbiol. 1990 Sep;33(1):51-4. doi: 10.1099/00222615-33-1-51.
Listeria monocytogenes cells are ingested by protozoa such as Acanthamoeba sp. or Tetrahymena pyriformis. However, they are not killed, but survive within the protozoa and may multiply intracellularly. The protozoa are lysed within about 8 days, releasing viable L. monocytogenes. No co-existence was observed between L. monocytogenes and Tetrahymena. A co-culture of L. monocytogenes and Acanthamoeba sp. showed a decay of locomotive forms and release of listeria from vegetative protozoan cells whereas the bacteria were destroyed in cysts. These phenomena provide an insight into the pathogenesis of listeria infection in man and warm-blooded animals because intracellular processes occurring in protozoa after ingestion of L. monocytogenes may be similar to those observed in mammalian cells.
单核细胞增生李斯特菌细胞会被诸如棘阿米巴属或梨形四膜虫等原生动物摄取。然而，它们不会被杀死，而是在原生动物内存活并可能在细胞内繁殖。原生动物在大约8天内会裂解，释放出活的单核细胞增生李斯特菌。未观察到单核细胞增生李斯特菌与四膜虫共存。单核细胞增生李斯特菌与棘阿米巴属的共培养显示运动型态衰退以及李斯特菌从营养型原生动物细胞中释放出来，而细菌在包囊中被破坏。这些现象为了解人类和温血动物李斯特菌感染的发病机制提供了线索，因为摄入单核细胞增生李斯特菌后原生动物内发生的细胞内过程可能与在哺乳动物细胞中观察到的过程相似。
