Fang Ye
Biochemical Technologies, Science and Technology Division, Corning Inc., Sullivan Park, Corning, NY 14831, Tele: 607-9747203.
Drug Discov Today Technol. 2011;7(1):e5-e11. doi: 10.1016/j.ddtec.2010.05.001.
Label-free biosensors offer integrated, kinetic and multi-parametric measures of receptor biology and ligand pharmacology in whole cells. Being highly sensitive and pathway-unbiased, label-free receptor assays can be used to probe the systems cell biology including pleiotropic signaling of receptors, and to characterize the functional selectivity and phenotypic pharmacology of ligand molecules. These assays provide a new dimension for elucidating receptor biology and for facilitating drug discovery.
无标记生物传感器能够对活细胞中的受体生物学和配体药理学进行综合、动力学和多参数测量。无标记受体分析具有高灵敏度且不受信号通路限制,可用于探究系统细胞生物学,包括受体的多效性信号传导,并可用于表征配体分子的功能选择性和表型药理学。这些分析为阐明受体生物学和促进药物发现提供了新的维度。