Hospital Universitario, Universidade Federal de Santa Catarina, Brazil.
Braz J Infect Dis. 2010 Sep-Oct;14(5):508-9.
This study evaluated the clonal spread of carbapenem-resistant P. aeruginosa producing SPM-1 type metallo-β-lactamase (MBL), at the university hospital of Florianópolis, Santa Catarina, Brazil, compared to an epidemic clone previously reported, as well as strains collected in other three Brazilian states. Among the isolates, 17 (62%) were clonal and highly related to strains from other regions of Brazil. Six clonal strains harbored the blaSPM-1 gene. The finding of a unique SPM-1 producer clone suggests that its dissemination has contributed to the high resistance to carbapenems in Brazilian hospitals.
本研究评估了巴西圣卡塔琳娜州弗洛里亚诺波利斯大学医院产 SPM-1 型金属β-内酰胺酶(MBL)的碳青霉烯类耐药铜绿假单胞菌的克隆传播情况,与之前报道的流行克隆株以及在其他三个巴西州收集的菌株进行了比较。在这些分离株中,17 株(62%)具有克隆性,与来自巴西其他地区的菌株高度相关。6 株克隆株携带 blaSPM-1 基因。发现独特的 SPM-1 产生克隆株提示其传播可能导致巴西医院对碳青霉烯类药物的高度耐药。