Sarvetnick N, Fox H S
Department of Developmental Biology, Genetech, Inc., South San Francisco, CA 94080.
Mol Biol Med. 1990 Aug;7(4):323-31.
The sexual difference in the incidence of autoimmune diseases has remained an enigma for many years. In the examination of the induction of autoimmunity in transgenic mice, evidence has been obtained further implicating the lymphokine interferon-gamma in the etiology of autoimmunity. Sex steroid regulation of the production of this molecule, as well as other cytokines, may help explain the gender-specific differences in the immune system, including autoimmunity.
自身免疫性疾病发病率的性别差异多年来一直是个谜。在对转基因小鼠自身免疫诱导的研究中，已获得进一步证据，表明淋巴因子干扰素-γ与自身免疫的病因有关。性激素对该分子以及其他细胞因子产生的调节，可能有助于解释免疫系统中的性别特异性差异，包括自身免疫性疾病。
