Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.
Arch Gynecol Obstet. 2011 Apr;283(4):837-43. doi: 10.1007/s00404-010-1829-y. Epub 2011 Jan 11.
Despite breast cancer diagnosis and treatment, women of childbearing age often desire a pregnancy. Since the average age of women giving birth for the first time is increasing, many young patients diagnosed with breast cancer have not started or completed their family planning. Thus, gynecologists and oncologists are confronted more often with the question of childbearing after breast cancer. Current data from retrospective trials do not suggest an increased risk of a recurrence or progress of the disease associated with pregnancy after stage-adjusted treatment. Also, the risk of fetal malformations and damage to the fetus after chemotherapy and/or hormone therapy seems similar to that in the general population. Women who receive chemotherapy are advised to wait at least 6 months before they attempt to conceive. The question whether to become pregnant must be discussed individually with the patient, based on tumor characteristics, stage of the disease and patient's wishes.
尽管乳腺癌的诊断和治疗后,育龄妇女往往渴望怀孕。由于初产妇的平均年龄增加,许多年轻的患者被诊断为乳腺癌尚未开始或完成计划生育。因此,妇科医生和肿瘤医生更经常面临乳腺癌后的生育问题。目前来自回顾性试验的数据并未提示与调整后的治疗后妊娠相关的疾病复发或进展风险增加。此外,化疗和/或激素治疗后胎儿畸形和胎儿损伤的风险似乎与普通人群相似。接受化疗的妇女建议至少等待 6 个月后再尝试怀孕。是否怀孕的问题必须根据肿瘤特征、疾病分期和患者的意愿与患者个体讨论。