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[直肠癌切除术后膜性肾病的临床改善]

[Clinical improvement of membranous nephropathy after a resection of rectal cancer].

作者信息

Kawamoto Shunji, Yoshida Takahisa

机构信息

Dept. of Surgery, Fukuoka Tokushukai Medical Center.

出版信息

Gan To Kagaku Ryoho. 2010 Nov;37(12):2614-6.

Abstract

A 71-year-old man was admitted by systemically massive edema and advanced rectal cancer. His hemoglobin or serum albumin level was 7.5 g/dL or 1.2 g/dL. Proteinuria ranged from 1.8 to 3.8 g/day. Massive effusion in chest and abdomen was obvious with low oxygenation and unstable hemodynamic state. Renal biopsy showed membranous nephropathy. Abdomino-perineal resection of the rectum was performed. Specimens showed poorly differentiated adenocarcinoma. The classification was type 1, 90 × 85 mm, pAI (seminal grand), pN3, sH0, sP0, cM0: fStage IIIb. The nephrotic syndrome was evidently improved with no urinary excretion of albumin at forty-postoperative day. The perioperative management allowed a surgical resection to be undertaken that led the clinical curability in rectal cancer as well as nephrotic syndrome.

摘要

一名71岁男性因全身性重度水肿和晚期直肠癌入院。他的血红蛋白或血清白蛋白水平分别为7.5 g/dL或1.2 g/dL。蛋白尿范围为1.8至3.8 g/天。胸腹部大量积液明显,伴有低氧血症和血流动力学状态不稳定。肾活检显示为膜性肾病。行腹会阴联合直肠癌切除术。标本显示为低分化腺癌。分类为1型,90×85 mm,pAI(精囊),pN3,sH0,sP0,cM0:fStage IIIb。术后第40天,肾病综合征明显改善,无白蛋白尿排出。围手术期管理使得能够进行手术切除,从而实现了直肠癌以及肾病综合征的临床治愈。

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