Braidwood J C, Henry N W
Rose Cottage Veterinary Centre, Cheshire.
Vet Rec. 1990 Sep 22;127(12):297-301.
Two similar groups of 14 calves were housed and fed identically in individual pens on a calf-rearing farm. The groups were balanced for weight and immunological status as determined by zinc sulphate turbidity values. When an outbreak of enteric and respiratory disease occurred one group was treated with 20 mg chlortetracycline hydrochloride/kg bodyweight daily for seven consecutive days, by adding the active ingredient to the milk replacer, while the other group was left untreated. Both groups received additional therapy as required. The calves were examined daily during the period of treatment and the clinical observations were assessed and analysed statistically. There was a significant difference between the clinical scores of the two groups on the second day of treatment (P less than 0.05) and on all subsequent days (P less than 0.01) indicating that the calves receiving chlortetracycline hydrochloride were less affected by the disease outbreak. The abnormal enteric and respiratory signs were associated with several potential pathogens including bacteria, viruses and protozoa. The treatment was therefore effective against enteric and respiratory disease involving several organisms.
在一个犊牛养殖场，将两组各14头相似的犊牛安置在个体栏舍中，并给予相同的饲养。根据硫酸锌浊度值确定，两组犊牛在体重和免疫状态方面保持平衡。当发生肠道和呼吸道疾病疫情时，一组犊牛连续7天每天按20毫克盐酸金霉素/千克体重进行治疗，方法是将活性成分添加到代乳粉中，而另一组不进行治疗。两组均根据需要接受额外治疗。在治疗期间每天对犊牛进行检查，并对临床观察结果进行评估和统计分析。在治疗的第二天，两组的临床评分存在显著差异（P小于0.05），在随后的所有日子里差异也很显著（P小于0.01），这表明接受盐酸金霉素治疗的犊牛受疾病疫情的影响较小。异常的肠道和呼吸道症状与包括细菌、病毒和原生动物在内的几种潜在病原体有关。因此，该治疗方法对涉及多种病原体的肠道和呼吸道疾病有效。
