Belfor Theodore R
OrthoSmile, Inc., Catskill, NY, USA.
N Y State Dent J. 2010 Nov;76(6):18-21.
It is the purpose of this article to introduce a functional orthopedic/orthodontic appliance, the Homeoblock (Figure 1), which, when worn at night (3 p.m. to 8 a.m.), alters oral function and produces a gene environmental interaction that results in an epigenetic response, namely, the expression of unexpressed genes in adult patients. The results of the case studies presented are evaluated using state-of-the-art, three-dimensional technologies: cone beam computerized tomography combined with Dolphin and Analyze 10.0 software (Mayo Clinic). The results, in so-called non-growing adult patients, can only be attributed to gene expression.
本文旨在介绍一种功能性矫形/正畸矫治器——同源阻滞器（图1），该矫治器在夜间（下午3点至上午8点）佩戴时，可改变口腔功能并产生基因-环境相互作用，从而引发表观遗传反应，即在成年患者中表达未表达的基因。所呈现的病例研究结果采用了最先进的三维技术进行评估：锥形束计算机断层扫描结合Dolphin和Analyze 10.0软件（梅奥诊所）。在所谓的成年非生长型患者中，这些结果只能归因于基因表达。
