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故事回忆测试在轻度认知障碍和阿尔茨海默病患者中的作用。

The usefulness of the story recall test in patients with mild cognitive impairment and Alzheimer's disease.

机构信息

Clinical Neuroscience Center & Neurology, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.

出版信息

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2011 Mar;18(2):214-29. doi: 10.1080/13825585.2010.530221. Epub 2011 Jan 12.

DOI:10.1080/13825585.2010.530221
PMID:21229403
Abstract

BACKGROUND

The story recall test (SRT) is one of the most reliable neuropsychological assessments for evaluating verbal memory function in order to distinguish between individuals with normal aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD). The SRT is analogous to the logical memory test in Wechsler Memory Scale-III, which has recently been developed and standardized to apply to older adults in Korea. The purpose of this study was to examine the usefulness of the SRT and its ability to discriminate between normal cognitive aging and patients with MCI or AD.

METHODS

One hundred and twelve patients with MCI, 97 patients with AD, and 53 healthy elderly adults participated in this study. The SRT was compared with the Clinical Dementia Rating (CDR), Global Deterioration Scale (GDS), Korean version of the Mini Mental State Examination (K-MMSE), and the Korean version of the Hopkins Verbal Learning Test (K-HVLT).

RESULTS

The SRT was well-correlated with the dementia rating scales and the K-HVLT. However, the sensitivity and specificity of the SRT was greatly influenced by the level of education of the subjects.

CONCLUSIONS

The SRT is a sensitive measurement of verbal memory function that can be used in clinical settings to discriminate between normal memory functioning and the very early and moderate stages of AD in a Korean population. Moreover, it is important to recognize that the SRT is more appropriate for subjects with a high level of education rather than a low level of education to differentiate normal cognitive aging from MCI or AD.

摘要

背景

故事回忆测试(SRT)是评估言语记忆功能最可靠的神经心理学评估之一,用于区分正常衰老、轻度认知障碍(MCI)和阿尔茨海默病(AD)患者。SRT 类似于韦氏记忆量表-III 中的逻辑记忆测试,该测试最近已在韩国开发并标准化,适用于老年人。本研究旨在检验 SRT 的有效性及其区分正常认知衰老和 MCI 或 AD 患者的能力。

方法

本研究共纳入 112 例 MCI 患者、97 例 AD 患者和 53 名健康老年人。将 SRT 与临床痴呆评定量表(CDR)、总体衰退量表(GDS)、韩国简易精神状态检查(K-MMSE)和韩国霍普金斯词语学习测验(K-HVLT)进行比较。

结果

SRT 与痴呆评定量表和 K-HVLT 高度相关。然而,SRT 的敏感性和特异性受受试者教育水平的影响较大。

结论

SRT 是一种敏感的言语记忆功能测量方法,可用于临床区分正常记忆功能和韩国人群中 AD 的早期和中度阶段。此外,需要认识到 SRT 更适用于教育程度较高的受试者,而不是教育程度较低的受试者,以区分正常认知衰老与 MCI 或 AD。

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