Petta E, Sotiropoulou-Bonikou G, Kourelis K, Melachrinou M, Bonikos D S
Department of Pathology, School of Medicine, University of Patras, Patras, Greece.
J BUON. 2010 Oct-Dec;15(4):740-5.
the peroxisome proliferator-activated receptor γ (PPARγ), known to play a key role in homeostatic biological pathways, is also implicated in the process of carcinogenesis. Ligands for PPARγ and its heterodimeric partner, retinoid-X receptor (RXR), have exhibited anticancer effects both in vitro and in vivo. Unexpectedly, some studies suggested that PPARγ ligands may stimulate cancer formation. This study aimed to estimate the signaling of PPARγ-RXRα heterodimer in bladder urothelial carcinomas (BUC).
we studied PPARγ and RXRα expression in specimens obtained from 97 patients with BUC of various grades and stages using immunohistochemistry.
PPARγ expression was significantly downregulated with BUC stage and grade progression, and the dynamics of this phenomenon was significantly influenced by RXRα's level of expression.
the positive association of PPARγ expression in BUC with more differentiated, non-invasive tumors is strengthened by the presence of RXRα. This knowledge could probably be of use in the development of new chemotherapeutic agents.
过氧化物酶体增殖物激活受体γ（PPARγ）在稳态生物学途径中发挥关键作用，同时也与致癌过程有关。PPARγ及其异源二聚体伴侣维甲酸X受体（RXR）的配体在体外和体内均表现出抗癌作用。出乎意料的是，一些研究表明PPARγ配体可能会刺激癌症形成。本研究旨在评估膀胱尿路上皮癌（BUC）中PPARγ-RXRα异源二聚体的信号传导。
我们使用免疫组织化学研究了从97例不同分级和分期的BUC患者获得的标本中PPARγ和RXRα的表达。
PPARγ表达随着BUC分期和分级进展而显著下调，并且这种现象的动态变化受到RXRα表达水平的显著影响。
RXRα的存在加强了BUC中PPARγ表达与更分化、非侵袭性肿瘤的正相关。这一知识可能有助于开发新的化疗药物。
