Hwang P L, How B E
Department of Physiology, Faculty of Medicine, National University of Singapore.
Oncology. 1990;47(6):495-500. doi: 10.1159/000226879.
We have detected specific high-affinity binding sites for nonsteroidal antiestrogens in 98% of 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. Since recent studies have suggested that these binding sites may be involved in the regulation of cell growth and proliferation, we attempted to define a possible relationship between the growth of these hormone-dependent tumors and their antiestrogen-binding site content. Rats bearing such tumors were either treated with haloperidol (to increase prolactin secretion and stimulate tumor growth) or oophorectomized (to reduce circulating estrogen concentration and suppress tumor growth). Compared with controls, haloperidol treatment clearly enhanced tumor growth while oophorectomy induced tumor regression, but neither procedure had any effect on the antiestrogen-binding site concentration. Furthermore, tumors which responded to endocrine manipulation had similar antiestrogen-binding site concentrations as tumors which did not respond. We conclude that (1) the alterations in tumor growth induced by these endocrine manipulations are probably not mediated through a change in antiestrogen-binding site concentration, and (2) the tumor concentration of these binding sites is not under estrogen or prolactin control.
我们在7,12-二甲基苯并(a)蒽诱导的大鼠乳腺肿瘤中，检测到98%存在非甾体类抗雌激素的特异性高亲和力结合位点。由于近期研究表明这些结合位点可能参与细胞生长和增殖的调节，我们试图确定这些激素依赖性肿瘤的生长与其抗雌激素结合位点含量之间可能存在的关系。携带此类肿瘤的大鼠，要么用氟哌啶醇治疗（以增加催乳素分泌并刺激肿瘤生长），要么进行卵巢切除术（以降低循环雌激素浓度并抑制肿瘤生长）。与对照组相比，氟哌啶醇治疗明显促进肿瘤生长，而卵巢切除术则导致肿瘤消退，但这两种操作均未对抗雌激素结合位点浓度产生任何影响。此外，对内分泌操作有反应的肿瘤与无反应的肿瘤，其抗雌激素结合位点浓度相似。我们得出结论：(1) 这些内分泌操作诱导的肿瘤生长改变，可能不是通过抗雌激素结合位点浓度的变化介导的；(2) 这些结合位点的肿瘤浓度不受雌激素或催乳素的控制。
