静脉注射普罗帕酮可降低猪除颤所需的能量。

Intravenous propafenone reduces energy requirements for defibrillation in pigs.

作者信息

Montenero A S, Bombardieri G, Barilaro C, Di Francesco P, Santarelli P, Calvi V, Schiavello R, Alessandrini F, Pisanò E, Salsano M

机构信息

Department of Cardiology and Cardiac Surgery, Catholic University, Rome.

出版信息

Cardiologia. 1990 Apr;35(4):291-4.

PMID:2123131

Abstract

The effect of antiarrhythmic drugs on defibrillation threshold have become an important issue with the increasing use of the automatic implantable cardioverter defibrillator (AICD). In several reports antiarrhythmic therapy has been found to affect the energy required for defibrillation; the present study examined the effects of intravenous propafenone on defibrillation threshold in open chest, anesthetized pigs. Twenty health pigs were studied; 10 pigs free from any drugs (Group 1) and 10 pigs after a constant iv infusion of 0.04 mg/kg/min of propafenone (Group 2). Defibrillation threshold was 21 +/- 5, 20 +/- 5, 21 +/- 6, 19 +/- 4 and 19 +/- 6 J in Group 1 and 20 +/- 7, 18 +/- 9, 15 +/- 5, 14 +/- 7, 9 +/- 6 J in Group 2, respectively at 20, 40, 60, 80 min (p value respectively NS, NS, less than 0.05, less than 0.01, less than 0.001). We conclude that intravenous propafenone reduces the energy requirements for defibrillation in experimental animals.

摘要

随着植入式自动心脏除颤器（AICD）使用的增加，抗心律失常药物对除颤阈值的影响已成为一个重要问题。在一些报告中，已发现抗心律失常治疗会影响除颤所需的能量；本研究在开胸麻醉猪身上研究了静脉注射普罗帕酮对除颤阈值的影响。研究了20只健康猪；10只未使用任何药物的猪（第1组）和10只以0.04mg/kg/min的恒定速度静脉输注普罗帕酮的猪（第2组）。第1组在20、40、60、80分钟时的除颤阈值分别为21±5、20±5、21±6、19±4和19±6焦耳，第2组分别为20±7、18±9、15±5、14±7、9±6焦耳（p值分别为无统计学意义、无统计学意义、小于0.05、小于0.01、小于0.001）。我们得出结论，静脉注射普罗帕酮可降低实验动物的除颤能量需求。