源和汇：异质环境中的进化随机模型。
Sources and sinks: a stochastic model of evolution in heterogeneous environments.
机构信息
Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093, USA.
出版信息
Phys Rev Lett. 2010 Dec 10;105(24):248104. doi: 10.1103/PhysRevLett.105.248104. Epub 2010 Dec 8.
Abstract
We study evolution driven by spatial heterogeneity in a stochastic model of source-sink ecologies. A sink is a habitat where mortality exceeds reproduction so that a local population persists only due to immigration from a source. Immigrants can, however, adapt to conditions in the sink by mutation. To characterize the adaptation rate, we derive expressions for the first arrival time of adapted mutants. The joint effects of migration, mutation, birth, and death result in two distinct parameter regimes. These results may pertain to the rapid evolution of drug-resistant pathogens and insects.
摘要
我们在源-汇生态系统的随机模型中研究了由空间异质性驱动的进化。汇是一个死亡率超过繁殖率的栖息地，因此一个局部种群之所以能够持续存在，仅仅是因为有来自源的移民。然而，移民可以通过突变来适应汇中的条件。为了描述适应率，我们推导出了适应突变体的首次到达时间的表达式。迁移、突变、出生和死亡的共同作用导致了两个不同的参数区域。这些结果可能与耐药病原体和昆虫的快速进化有关。
相似文献
1
Sources and sinks: a stochastic model of evolution in heterogeneous environments.
Phys Rev Lett. 2010 Dec 10;105(24):248104. doi: 10.1103/PhysRevLett.105.248104. Epub 2010 Dec 8.
2
Temporal variation can facilitate niche evolution in harsh sink environments.
Am Nat. 2004 Aug;164(2):187-200. doi: 10.1086/422343. Epub 2004 Jul 1.
3
Transient local adaptation and source-sink dynamics in experimental populations experiencing spatially heterogeneous environments.
Proc Biol Sci. 2019 Jun 26;286(1905):20190738. doi: 10.1098/rspb.2019.0738.
4
Source-sink dynamics between transgenic and non-transgenic habitats and their role in the evolution of resistance.
J Econ Entomol. 2001 Jun;94(3):698-705. doi: 10.1603/0022-0493-94.3.698.
5
Stochastic population growth in spatially heterogeneous environments.
J Math Biol. 2013 Feb;66(3):423-76. doi: 10.1007/s00285-012-0514-0. Epub 2012 Mar 18.
6
The effects of density dependence and immigration on local adaptation and niche evolution in a black-hole sink environment.
Theor Popul Biol. 1999 Jun;55(3):283-96. doi: 10.1006/tpbi.1998.1405.
7
Role of sex and migration in adaptation to sink environments.
Evolution. 2014 Aug;68(8):2296-305. doi: 10.1111/evo.12440. Epub 2014 May 23.
8
Allee effects, immigration, and the evolution of species' niches.
Am Nat. 2004 Feb;163(2):253-62. doi: 10.1086/381408. Epub 2004 Feb 13.
9
On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient.
Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10775-80. doi: 10.1073/pnas.1117716109. Epub 2012 Jun 18.
10
Evolution with stochastic fitness and stochastic migration.
PLoS One. 2009 Oct 9;4(10):e7130. doi: 10.1371/journal.pone.0007130.
引用本文的文献
1
Deciphering population-level response under spatial drug heterogeneity on microhabitat structures.
bioRxiv. 2025 Mar 2:2025.02.13.638200. doi: 10.1101/2025.02.13.638200.
2
Modeling spatial evolution of multi-drug resistance under drug environmental gradients.
PLoS Comput Biol. 2024 May 31;20(5):e1012098. doi: 10.1371/journal.pcbi.1012098. eCollection 2024 May.
3
Substrate geometry affects population dynamics in a bacterial biofilm.
Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2315361121. doi: 10.1073/pnas.2315361121. Epub 2024 Apr 15.
4
Modeling spatial evolution of multi-drug resistance under drug environmental gradients.
bioRxiv. 2023 Nov 17:2023.11.16.567447. doi: 10.1101/2023.11.16.567447.
5
Bacterial motility can govern the dynamics of antibiotic resistance evolution.
Nat Commun. 2023 Sep 11;14(1):5584. doi: 10.1038/s41467-023-41196-8.
6
A coevolution experiment between and reveals parallel mutations that reduce antibiotic susceptibility.
Microbiology (Reading). 2023 Feb;169(2). doi: 10.1099/mic.0.001267.
7
Evolution in alternating environments with tunable interlandscape correlations.
Evolution. 2021 Jan;75(1):10-24. doi: 10.1111/evo.14121. Epub 2020 Dec 13.
8
Role of a Concentration Gradient in Malaria Drug Resistance Evolution: A Combined within- and between-Hosts Modelling Approach.
Sci Rep. 2020 Apr 10;10(1):6219. doi: 10.1038/s41598-020-63283-2.
9
Competing evolutionary paths in growing populations with applications to multidrug resistance.
PLoS Comput Biol. 2019 Apr 15;15(4):e1006866. doi: 10.1371/journal.pcbi.1006866. eCollection 2019 Apr.
10
Environmental heterogeneity can tip the population genetics of range expansions.
Elife. 2019 Apr 12;8:e44359. doi: 10.7554/eLife.44359.
本文引用的文献
1
Evidence that adaptation in Drosophila is not limited by mutation at single sites.
PLoS Genet. 2010 Jun 17;6(6):e1000924. doi: 10.1371/journal.pgen.1000924.
2
Source-sink dynamics shape the evolution of antibiotic resistance and its pleiotropic fitness cost.
Proc Biol Sci. 2007 Sep 22;274(1623):2351-6. doi: 10.1098/rspb.2007.0640.
3
Empirical fitness landscapes reveal accessible evolutionary paths.
Nature. 2007 Jan 25;445(7126):383-6. doi: 10.1038/nature05451.
4
Haplotype diversity in "source-sink" dynamics of Escherichia coli urovirulence.
J Mol Evol. 2007 Feb;64(2):204-14. doi: 10.1007/s00239-006-0063-5. Epub 2006 Dec 19.
5
Census error and the detection of density dependence.
J Anim Ecol. 2006 Jul;75(4):837-51. doi: 10.1111/j.1365-2656.2006.01121.x.
6
Source-sink dynamics of virulence evolution.
Nat Rev Microbiol. 2006 Jul;4(7):548-55. doi: 10.1038/nrmicro1446.
7
Allee effects, immigration, and the evolution of species' niches.
Am Nat. 2004 Feb;163(2):253-62. doi: 10.1086/381408. Epub 2004 Feb 13.
8
The phenomenology of niche evolution via quantitative traits in a 'black-hole' sink.
Proc Biol Sci. 2003 Jan 22;270(1511):215-24. doi: 10.1098/rspb.2002.2219.
9
When sources become sinks: migrational meltdown in heterogeneous habitats.
Evolution. 2001 Aug;55(8):1520-31. doi: 10.1111/j.0014-3820.2001.tb00672.x.
10
Adaptation to marginal habitats: contrasting influence of the dispersal rate on the fate of alleles with small and large effects.
Proc Biol Sci. 2000 Jul 7;267(1450):1315-20. doi: 10.1098/rspb.2000.1144.
Zotero 插件