Department of Molecular Neurobiology, University of Groningen, The Netherlands.
FEBS J. 2011 Apr;278(6):888-98. doi: 10.1111/j.1742-4658.2011.08017.x. Epub 2011 Feb 8.
Extensive research has been performed to unravel the mechanistic signaling pathways mediated by tumor necrosis factor receptor 1 (TNFR1), by contrast there is limited knowledge on cellular signaling upon activation of TNFR2. Recently published data have revealed that these two receptors not only function independently, but also can influence each other via cross-talk between the different signaling pathways initiated by TNFR1 and TNFR2 stimulation. Furthermore, the complexity of this cross-talk is also dependent on the different signaling kinetics between TNFR1 and TNFR2, by which a delicate balance between cell survival and apoptosis can be maintained. Some known signaling factors and the kinetics that are involved in the receptor cross-talk between TNFR1 and TNFR2 are the topic of this review.
已经进行了广泛的研究来阐明肿瘤坏死因子受体 1（TNFR1）介导的机制信号通路，相比之下，关于 TNFR2 激活时的细胞信号知之甚少。最近发表的数据表明，这两个受体不仅独立发挥作用，而且还可以通过 TNFR1 和 TNFR2 刺激引发的不同信号通路之间的串扰相互影响。此外，这种串扰的复杂性还取决于 TNFR1 和 TNFR2 之间不同的信号动力学，通过这种动力学可以维持细胞存活和凋亡之间的微妙平衡。本文综述了参与 TNFR1 和 TNFR2 受体串扰的一些已知信号因子和动力学。
