C.W. Patrick, Jr. and L.V. McIntire are at the Cox Laboratory for Biomedical Engineering, Rice University, Houston, TX 77251-1892, USA.
Trends Cardiovasc Med. 1996 May;6(4):122-9. doi: 10.1016/1050-1738(96)00023-0.
Bioengineers and vascular biologists have enjoyed a successful symbiosis over the last two decades. In particular, bioengineers and life scientists have begun to understand the cellular and molecular mechanisms that underlie normal physiological and pathophysiological vascular biology. One conclusion of importance is that fluid mechanics and mass transfer are closely integrated with and actively modulate blood and vascular cell function. Examples include flow regulation of receptor specificity in leukocyte/endothelial cell adhesion and wall shear stress and mechanical strain modulation of gene expression in endothelial and smooth muscle cells. The continued synthesis of cell and molecular biology with systems analysis, mass transport phenomena, and quantitative modeling will allow the development of patientspecific therapeutics with applications in inflammation, atherosclerosis, thrombosis, sickle cell disease, and cancer metastasis.
在过去的二十年中，生物工程师和血管生物学家一直相处融洽。特别是，生物工程师和生命科学家开始理解正常生理和病理生理血管生物学背后的细胞和分子机制。一个重要的结论是，流体力学和质量传递与血液和血管细胞功能密切结合并积极调节。例如，在白细胞/内皮细胞黏附中，流动调节受体特异性，壁切应力和机械应变调节内皮和平滑肌细胞中的基因表达。细胞和分子生物学与系统分析、质量输运现象和定量建模的持续综合将使针对炎症、动脉粥样硬化、血栓形成、镰状细胞病和癌症转移等疾病的个体化治疗的发展成为可能。
