Northeastern University and Massachusetts General Hospital,Boston 02115,USA.
Trends Cardiovasc Med. 1996 Oct;6(7):226-32. doi: 10.1016/S1050-1738(96)00093-X.
Although the exact mechanisms of atherogenesis have not yet been elaborated, it is believed to be an inflammatory immunological response of the injured intima. The molecules and cells involved in this inflammatory response may provide specific targets for the development of novel diagnostic modalities. The present review deals with use of antibodies specific for the neoantigens of the vascular smooth muscle cells of the transformed synthetic phenotype for the detection of atherosclerotic lesions, as well as the potential use of the upregulation of the purinoceptors as indicators of the phenotypic transformation of these cells. In addition to the recognition of atherosclerotic lesions, such a strategy may also help identify accelerated proliferating smooth muscle cells associated with postangioplastic restenosis. © 1996, Elsevier Science Inc. (Trends Cardiovasc Med 1996;6:226-232).
尽管动脉粥样硬化的确切形成机制尚未阐明，但人们认为它是受伤内膜的炎症免疫反应。参与这种炎症反应的分子和细胞可能为新的诊断方式的发展提供特定的靶点。本综述涉及使用针对转化合成表型的血管平滑肌细胞的新抗原的抗体来检测动脉粥样硬化病变，以及上调嘌呤能受体作为这些细胞表型转化的指标的潜在用途。除了识别动脉粥样硬化病变外，这种策略还可能有助于识别与血管成形术后再狭窄相关的增殖活跃的平滑肌细胞。©1996，Elsevier Science Inc.（趋势心血管医学 1996；6:226-232）。
