Grynberg M, Hesters L, Bénard J, Trèves R, Fanchin R, Frydman R, Frydman N
Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 157, rue de la Porte-de-Trivaux, 92141 Clamart, France.
J Gynecol Obstet Biol Reprod (Paris). 2011 Apr;40(2):103-8. doi: 10.1016/j.jgyn.2010.11.004. Epub 2011 Jan 13.
Although female cancer incidence may be on rise, antineoplastic regimens have become more successful. As a result, an increasing number of women with cancer survive to endure the long-term consequences of chemotherapy. One of the most important long-term consequences of cancers treatments in young female is premature ovarian failure and infertility. Because of the increasing survival rates, many of these young women are seeking methods to preserve their fertility. Currently, embryo/oocytes cryoporeservation obtained after ovarian stimulation appears to provide the best fertility preservation option. However, patients may not have sufficient time to undergo ovarian stimulation prior to chemotherapy and/or the hormones used in ovarian stimulation are contra-indicated for estrogen-dependant tumors. In vitro maturation of oocytes (IVM) has been suggested to avoid ovarian stimulation and time requirement in patients with cancer, and can be combined with ovarian tissue cryobanking. In this review, we will discuss the position of IVM in the strategy of fertility preservation in young women.
尽管女性癌症发病率可能在上升，但抗肿瘤治疗方案已变得更加成功。因此，越来越多的癌症女性存活下来，承受化疗的长期后果。年轻女性癌症治疗最重要的长期后果之一是卵巢早衰和不孕。由于存活率不断提高，许多这些年轻女性正在寻求保留生育能力的方法。目前，卵巢刺激后获得的胚胎/卵母细胞冷冻保存似乎提供了最佳的生育力保存选择。然而，患者在化疗前可能没有足够的时间进行卵巢刺激，和/或卵巢刺激中使用的激素对雌激素依赖性肿瘤是禁忌的。卵母细胞体外成熟（IVM）已被建议用于避免癌症患者的卵巢刺激和时间要求，并且可以与卵巢组织冷冻保存相结合。在这篇综述中，我们将讨论IVM在年轻女性生育力保存策略中的地位。
