Tripathy Sujit Kumar, Goyal Tarun, Sen Ramesh Kumar, Meena Dharam Singh, Gupta Nalini, Agrawal Kanhaiyalal
Department of Orthopedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Foot (Edinb). 2011 Mar;21(1):48-51. doi: 10.1016/j.foot.2010.12.003. Epub 2011 Jan 12.
A 22-year-young adult presented with a painless swelling of distal fibula on right side for 3-month duration. He had no constitutional symptoms and there was full range of painfree ankle movement. Radiographs showed cortical breech with an osteolytic lesion in lateral malleolus. Magnetic Resonance Imaging showed T2W hyperintense signal in the distal fibula. It further revealed involvement of tendo Achilles and paroneal tendons. Fine needle aspiration cytology showed epitheloid granuloma and Langhans giant cells. The Mycobacterium tuberculosis DNA could be identified on polymerase chain reaction. The patient received 18 months of antitubercular treatment and the lesion subsided. There is no recurrence even after 3 years of follow up. A strong suspicion of tuberculosis should be considered in any bony swelling of a patient from endemic area, even at atypical sites. Polymerase chain reaction analysis should be performed in addition to radiological and histological examination of the lesion to establish the diagnosis. Early treatment with antitubercular therapy decreases the morbidity and avoids the possibility of surgical intervention.
一名22岁的青年男性,右侧腓骨远端无痛性肿胀3个月。他无全身症状,踝关节活动自如且无疼痛。X线片显示皮质破坏,外踝有溶骨性病变。磁共振成像显示腓骨远端T2加权像呈高信号。进一步显示跟腱和腓骨肌腱受累。细针穿刺细胞学检查显示上皮样肉芽肿和朗汉斯巨细胞。聚合酶链反应可鉴定出结核分枝杆菌DNA。该患者接受了18个月的抗结核治疗,病变消退。随访3年无复发。对于来自流行地区患者的任何骨肿胀,即使在非典型部位,也应高度怀疑结核病。除了对病变进行放射学和组织学检查外,还应进行聚合酶链反应分析以明确诊断。早期抗结核治疗可降低发病率并避免手术干预的可能性。