抗组胺减充血剂预防感冒儿童急性中耳炎。
An antihistamine decongestant in the prevention of acute otitis media in children with colds.
出版信息
Can Fam Physician. 1990 Oct;36:1749-53.
Most clinical drug trials relating to acute otitis media have evaluated medications in terms of treatment. In this randomized double-blind, cross-over study, the effectiveness of an antihistamine decongestant in the prevention of AOM was investigated, rather than the treatment. The medication/placebo was started at the onset of a cold and continued throughout its duration. No treatment effect was evident in the results obtained with 308 children who completed the eight-month study. However, the results indicated a strong relationship between colds and AOM, and a trend toward higher occurrence of AOM in children under four years of age.
大多数与急性中耳炎相关的临床药物试验都从治疗角度评估药物。在这项随机双盲交叉研究中，研究了一种抗组胺去充血剂在预防 AOM 方面的有效性，而不是治疗效果。药物/安慰剂在感冒开始时开始使用，并持续整个感冒期间。在完成了为期八个月研究的 308 名儿童中，结果并未显示出治疗效果。然而，结果表明感冒与 AOM 之间存在很强的关系，并且四岁以下儿童 AOM 的发生率呈上升趋势。
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