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使用多维基因组方法解析鳞状细胞癌。

Deciphering squamous cell carcinoma using multidimensional genomic approaches.

作者信息

Gibb Ewan A, Enfield Katey S S, Tsui Ivy F L, Chari Raj, Lam Stephen, Alvarez Carlos E, Lam Wan L

机构信息

Department of Integrative Oncology, British Columbia Cancer Agency Research Centre, Vancouver BC, Canada V5Z 1L3.

出版信息

J Skin Cancer. 2011;2011:541405. doi: 10.1155/2011/541405. Epub 2010 Dec 27.

DOI:10.1155/2011/541405
PMID:21234096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3017908/
Abstract

Squamous cell carcinomas (SqCCs) arise in a wide range of tissues including skin, lung, and oral mucosa. Although all SqCCs are epithelial in origin and share common nomenclature, these cancers differ greatly with respect to incidence, prognosis, and treatment. Current knowledge of genetic similarities and differences between SqCCs is insufficient to describe the biology of these cancers, which arise from diverse tissue origins. In this paper we provide a general overview of whole genome approaches for gene and pathway discovery and highlight the advancement of integrative genomics as a state-of-the-art technology in the study of SqCC genetics.

摘要

鳞状细胞癌（SqCCs）可发生于多种组织，包括皮肤、肺和口腔黏膜。尽管所有SqCCs均起源于上皮组织且具有共同的命名，但这些癌症在发病率、预后和治疗方面存在很大差异。目前关于SqCCs之间基因异同的认识不足以描述这些起源于不同组织的癌症的生物学特性。在本文中，我们对用于基因和通路发现的全基因组方法进行了概述，并强调了整合基因组学作为SqCC遗传学研究中的一项前沿技术的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/1ae1bd0c6f0a/JSC2011-541405.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/130cd6df4e16/JSC2011-541405.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/f3309f44a567/JSC2011-541405.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/4b6346705ffa/JSC2011-541405.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/198e08d4c2e5/JSC2011-541405.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/4cd5be43dbd4/JSC2011-541405.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/a2878d8401c2/JSC2011-541405.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/1ae1bd0c6f0a/JSC2011-541405.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/130cd6df4e16/JSC2011-541405.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/f3309f44a567/JSC2011-541405.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/4b6346705ffa/JSC2011-541405.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/198e08d4c2e5/JSC2011-541405.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/4cd5be43dbd4/JSC2011-541405.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/a2878d8401c2/JSC2011-541405.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b5a/3017908/1ae1bd0c6f0a/JSC2011-541405.007.jpg

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Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.综合基因组分析鉴定 BRF2 为肺鳞癌中一个新的谱系特异性癌基因。
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The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models.转化生长因子β信号通路在鳞状细胞癌中的作用：来自小鼠模型的经验教训。
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