Department of Public Health Dentistry, Dr. M.G.R. Educational and Research Institute, Thai Moogambigai Dental College and Hospital, Chennai 600107, Tamil Nadu, India.
Department of Clinical Sciences, Centre of Medical and Bio-Allied Health Sciences and Research Ajman University, Ajman P.O. Box 346, United Arab Emirates.
Molecules. 2024 May 20;29(10):2402. doi: 10.3390/molecules29102402.
Oral cancer (OC) is among the most common malignancies in the world. Despite advances in therapy, the worst-case scenario for OC remains metastasis, with a 50% survival rate. Therefore, it is critical to comprehend the pathophysiology of the condition and to create diagnostic and treatment plans for OC. The development of high-throughput genome sequencing has revealed that over 90% of the human genome encodes non-coding transcripts, or transcripts that do not code for any proteins. This paper describes the function of these different kinds of non-coding RNAs (ncRNAs) in OC as well as their intriguing therapeutic potential. The onset and development of OC, as well as treatment resistance, are linked to dysregulated ncRNA expression. These ncRNAs' potentially significant roles in diagnosis and prognosis have been suggested by their differing expression in blood or saliva. We have outlined every promising feature of ncRNAs in the treatment of OC in this study.
口腔癌 (OC) 是世界上最常见的恶性肿瘤之一。尽管治疗方法有所进步，但 OC 的最坏情况仍然是转移，存活率为 50%。因此，了解该疾病的病理生理学并为 OC 制定诊断和治疗计划至关重要。高通量基因组测序的发展表明，超过 90%的人类基因组编码非编码转录本，即不编码任何蛋白质的转录本。本文描述了这些不同类型的非编码 RNA（ncRNA）在 OC 中的功能及其有趣的治疗潜力。OC 的发生和发展以及治疗耐药性与 ncRNA 表达失调有关。它们在血液或唾液中的不同表达提示了这些 ncRNA 在诊断和预后方面的潜在重要作用。我们在这项研究中概述了 ncRNA 在治疗 OC 方面的每一个有前途的特征。
