Department of Cardiovascular Surgery, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, 6550 Fannin, Smith Tower, Suite 1401, Houston, TX 77030, USA.
Cardiol Res Pract. 2010 Dec 27;2011:781035. doi: 10.4061/2011/781035.
Metabolic syndrome significantly increases the risk for cardiovascular disease and chronic kidney disease. The increased risk for cardiovascular diseases can partly be caused by a prothrombotic state that exists because of abdominal obesity. Multiple observational studies have consistently shown that increased body mass index as well as insulin resistance and increased fasting insulin levels is associated with chronic kidney disease, even after adjustment for related disorders. Metabolic syndrome appears to be a risk factor for chronic kidney disease, likely due to the combination of dysglycemia and high blood pressure. Metabolic syndrome is associated with markedly reduced renal clinical benefit and increased progression to hemodialysis following endovascular intervention for atherosclerotic renal artery stenosis. Metabolic syndrome is associated with inferior early outcomes for dialysis access procedures.
代谢综合征显著增加了心血管疾病和慢性肾脏病的风险。心血管疾病风险的增加部分可能是由于腹部肥胖导致的血栓前状态。多项观察性研究一致表明，即使在调整了相关疾病后，体重指数增加、胰岛素抵抗和空腹胰岛素水平升高与慢性肾脏病有关。代谢综合征似乎是慢性肾脏病的一个危险因素，可能是由于血糖异常和高血压的共同作用。代谢综合征与血管内介入治疗粥样硬化性肾动脉狭窄后血液透析的临床获益显著降低和进展为血液透析的风险增加有关。代谢综合征与透析通路手术的早期结局较差有关。
