Croitoru Liliana, Trifan Anca, Maxim Maria Rusu, Girleanu Irina, Hulub Angela, Dimache Mihaela, Stanciu C
Suceava County Hospital, Gr.T. Popa University of Medicine and Pharmacy laşi.
Rev Med Chir Soc Med Nat Iasi. 2010 Jul-Sep;114(3):683-6.
First-degree relatives of colorectal cancer (CRC) patients are at increased risk for developing colorectal neoplasm, and current guidelines recommend screening colonoscopy in such individuals. The aim of this study was to evaluate the use of colonoscopy as the screening test in asymptomatic first-degree relatives of CRC patients.
Colonoscopy was performed in 102 asymptomatic individuals who had at least one first-degree relatives with CRC. Subjects included in the screening program were aged between 36 and 72 years, and majority came from two counties (Suceava, Iaşi) located in north-eastern Romania.
Thirty colorectal lesions were found in 17 individuals: two (6.6%) had adenocarcinomas, and remaining 15 patients had 28 polypoid lesions: 14 (46.6%) adenomas, 5 (16.6%) tubulovillous adenomas, 3 (10%) adenomas with high grade dysplasia and 6 (20%) had hyperplasic polyps.
Colonoscopy is a useful, feasible and safety initial screening tool for first-degree relatives of patients with CRC.
结直肠癌（CRC）患者的一级亲属患结直肠肿瘤的风险增加，当前指南建议对此类个体进行结肠镜筛查。本研究的目的是评估结肠镜检查作为CRC患者无症状一级亲属筛查试验的应用情况。
对102名至少有一名CRC一级亲属的无症状个体进行了结肠镜检查。纳入筛查项目的受试者年龄在36至72岁之间，大多数来自罗马尼亚东北部的两个县（苏恰瓦、雅西）。
在17名个体中发现了30处结直肠病变：2例（6.6%）患有腺癌，其余15例患者有28处息肉样病变：14例（46.6%）为腺瘤，5例（16.6%）为管状绒毛状腺瘤，3例（10%）为高级别异型增生腺瘤，6例（20%）为增生性息肉。
结肠镜检查是CRC患者一级亲属有用、可行且安全的初始筛查工具。
