Research Centre, Iranian Blood Transfusion Organisation, Tehran, Iran.
Blood Transfus. 2011 Jan;9(1):95-8. doi: 10.2450/2010.0032-10.
The aim of this study was to evaluate whether thawed plasma stored for 5 days at 1-6 ºC is appropriate for use.
Samples taken from thawed plasma units stored for 5 days at 1-6 ºC were prepared for assays of the levels of factor V, factor VIII, and factor X, and for measurements of the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The results obtained were then compared with those from other similar studies.
The average decreases in percentages of coagulation factors from day 1 to day 5 were 20% for factor V, 11% for factor X, and 25% for total factor VIII. The changes in the range of coagulation factors over the 5-day storage period were statistically significant, but the values remained within the haemostatic range. The average increases in the levels of PT and aPTT from day 1 to day 5 were also not clinically pathological.
Thawed fresh-frozen plasma stored for 5 days at 1-6 °C can be used in different cases of coagulopathy and can be used as an alternative to plasma frozen within 24 hours of phlebotomy.
本研究旨在评估在 1-6°C 下解冻并储存 5 天的血浆是否适合使用。
从在 1-6°C 下解冻并储存 5 天的血浆单位中抽取样本，以检测凝血因子 V、VIII 和 X 的水平，并测量活化部分凝血活酶时间 (aPTT) 和凝血酶原时间 (PT)。然后将获得的结果与其他类似研究进行比较。
从第 1 天到第 5 天，凝血因子的平均百分比下降分别为 20%的因子 V、11%的因子 X 和 25%的总因子 VIII。在 5 天的储存期内，凝血因子的变化范围具有统计学意义，但数值仍在止血范围内。PT 和 aPTT 水平从第 1 天到第 5 天的平均增加也没有临床病理学意义。
在 1-6°C 下解冻并储存 5 天的新鲜冷冻血浆可用于不同类型的凝血功能障碍，并可替代在采血后 24 小时内冷冻的血浆。
