Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
Vaccine. 2011 Mar 3;29(11):2071-8. doi: 10.1016/j.vaccine.2011.01.005. Epub 2011 Jan 14.
Genital herpes simplex virus (HSV) infections are common but results from vaccine trials with HSV-2 glycoprotein D (gD) have been disappointing. We therefore compared a similar HSV gD2 vaccine, to a further truncated gD2 vaccine, to a vaccine with gD2 plus gB2 and gH2/gL2 and to a vaccine with only gB2 and gH2/gL2 in a guinea pig model of genital herpes. All vaccines were administered with cationic liposome-DNA complexes (CLDC) as an adjuvant. All vaccines significantly decreased the severity of acute genital disease and vaginal virus replication compared to the placebo group. The majority of animals in all groups developed at least one episode of recurrent disease but the frequency of recurrent disease was significantly reduced by each vaccine compared to placebo. No vaccine was significantly more protective than gD2 alone for any of the parameters described above. No vaccine decreased recurrent virus shedding. When protection against acute infection of dorsal root ganglia and the spinal cord was evaluated all vaccines decreased the per cent of animal with detectable virus and the quantity of virus but again no vaccine was significantly more protective than another. Improvements in HSV-2 vaccines may require inclusion of more T cell targets, more potent adjuvants or live virus vaccines.
单纯疱疹病毒（HSV）感染很常见，但针对 HSV-2 糖蛋白 D（gD）的疫苗试验结果令人失望。因此，我们在生殖器疱疹豚鼠模型中比较了一种类似的 HSV gD2 疫苗、一种进一步截短的 gD2 疫苗、一种包含 gD2 加 gB2 和 gH2/gL2 的疫苗以及一种仅包含 gB2 和 gH2/gL2 的疫苗。所有疫苗均与阳离子脂质体-DNA 复合物（CLDC）作为佐剂联合使用。与安慰剂组相比，所有疫苗均显著降低了急性生殖器疾病和阴道病毒复制的严重程度。所有组中大多数动物至少发生了一次复发性疾病，但与安慰剂相比，每种疫苗都显著降低了复发性疾病的频率。在上述任何参数方面，没有一种疫苗比单独使用 gD2 更具保护作用。没有疫苗能减少复发性病毒脱落。当评估对背根神经节和脊髓的急性感染的保护作用时，所有疫苗均降低了检测到病毒的动物百分比和病毒数量，但同样没有一种疫苗比另一种疫苗更具保护作用。HSV-2 疫苗的改进可能需要包含更多的 T 细胞靶标、更有效的佐剂或活病毒疫苗。
