Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Hum Exp Toxicol. 2011 Oct;30(10):1575-83. doi: 10.1177/0960327110393762. Epub 2011 Jan 14.
Considering the potential adverse effects of selenium and iodine deficiencies, and frequency of intensive but improper use of insecticides, this study was designed to evaluate the effects of a pyrethroid insecticide, fenvalerate, on the oxidant/antioxidant status of liver using a rat model of iodine and/or selenium deficiency. The study was conducted on eight groups of 3-week old Wistar rats. Iodine and/or selenium deficiency was introduced by feeding the animals with a diet containing <0.005 mg selenium/kg and/or supplying with 1% sodium perchlorate containing drinking water for a period of 7 weeks. Fenvalerate exposure (100 mg/kg/d, i.p., for the last 7 days) in normal rats increased hepatic glutathione peroxidase activity and lipid peroxidation, decreased glutathione content, but did not change the activities of catalase or any of the superoxide dismutase forms; in iodine-deficient animals caused only the elevation of lipid peroxidation; in selenium-deficient animals and in combined iodine/selenium deficiency decreased glutathione peroxidase, increased catalase activities and lipid peroxidation, and decreased all the forms of superoxide dismutase activity only in combined deficiency. These results suggested that fenvalerate is an oxidant stress inducer in rat liver, and its potential effects on pro-oxidant/antioxidant balance may also be important for human populations, particularly with iodine and/or selenium deficiencies.
考虑到硒和碘缺乏的潜在不良影响，以及杀虫剂的过度和不当使用频率，本研究旨在使用碘和/或硒缺乏的大鼠模型评估拟除虫菊酯杀虫剂氰戊菊酯对肝脏氧化/抗氧化状态的影响。该研究在 8 组 3 周龄 Wistar 大鼠中进行。通过给动物喂食含硒量<0.005mg/kg 的饮食或供应含 1%高氯酸钠的饮用水，为期 7 周，引入碘和/或硒缺乏。在正常大鼠中，氰戊菊酯暴露（最后 7 天腹腔注射 100mg/kg/d）增加了肝谷胱甘肽过氧化物酶活性和脂质过氧化，降低了谷胱甘肽含量，但未改变过氧化氢酶或任何超氧化物歧化酶形式的活性；在碘缺乏动物中仅引起脂质过氧化升高；在硒缺乏动物中和在碘/硒联合缺乏时，谷胱甘肽过氧化物酶降低，过氧化氢酶活性和脂质过氧化增加，所有超氧化物歧化酶形式的活性仅在联合缺乏时降低。这些结果表明，氰戊菊酯是大鼠肝脏的氧化应激诱导剂，其对促氧化剂/抗氧化剂平衡的潜在影响对于人类，特别是对于碘和/或硒缺乏的人群，可能也很重要。
