Clune James E, Mulliken John B, Glowacki Julie, Arany Praveen R, Kulungowski Ann M, Rogers Gary F, Greene Arin K
Department of Plastic and Oral Surgery, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
J Craniofac Surg. 2011 Jan;22(1):319-23. doi: 10.1097/SCS.0b013e3181f7e0e2.
The purpose of this study was to determine whether particulate bone graft maintains its volume when used for onlay cranioplasty. Twenty-five adult, male, New Zealand white rabbits were divided into 5 groups (n = 5/group). Groups 1 to 3 were controls: group 1, untreated; group 2, sham procedure; and group 3, burring the cortical surface. Group s 4 and 5 had augmentation of the parietal bones with particulate graft harvested from the frontal bone with a brace and bit. The particulate graft was placed on native parietal bone (group 4) or on parietal bone that had been abraded to punctuate bleeding with an electric burr (group 5). Volume maintenance and osseointegration of the grafts were determined by micro-computed tomography and histology. At 16 weeks postoperatively, the mean (SD) volumes of the parietal bones in control groups 1, 2, and 3 were 555.8 (29.2), 550.8 (36.8), and 539.0 (39.0) mm, respectively. Immediately after cranioplasty, the mean (SD) volumes of augmented parietal bone were 846.0 (10.8) mm for group 4 and 831.8 (11.8) mm for group 5. Sixteen weeks postoperatively, 100% of the group 4 grafts had resorbed (551.8 [SD, 24.0] mm), and parietal volume was no different from controls (P = 0.89). Group 5 maintained 54.2% of volume (695.6 [SD, 22.0] mm), which was greater than those of the controls (P < 0.0001). Particulate graft may be used for onlay cranioplasty if the recipient site is burred. Approximately one half of the onlay graft is resorbed, and its original shape is not maintained.
本研究的目的是确定颗粒状骨移植用于覆盖式颅骨成形术时是否能保持其体积。25只成年雄性新西兰白兔被分为5组（每组n = 5）。第1至3组为对照组：第1组，未治疗；第2组，假手术；第3组，打磨皮质表面。第4组和第5组用钻和钻头从额骨采集颗粒状移植物对顶骨进行增强。颗粒状移植物置于天然顶骨上（第4组）或置于已用电钻打磨以刺破出血的顶骨上（第5组）。通过微型计算机断层扫描和组织学确定移植物的体积维持和骨整合情况。术后16周，第1、2和3组对照组顶骨的平均（标准差）体积分别为555.8（29.2）、550.8（36.8）和539.0（39.0）mm³。颅骨成形术后即刻，第4组增强顶骨的平均（标准差）体积为846.0（10.8）mm³，第5组为831.8（11.8）mm³。术后16周，第4组100%的移植物已吸收（551.8 [标准差，24.0] mm³），顶骨体积与对照组无差异（P = 0.89）。第5组维持了54.2%的体积（695.6 [标准差，22.0] mm³），大于对照组（P < 0.0001）。如果受体部位进行打磨，颗粒状移植物可用于覆盖式颅骨成形术。大约一半的覆盖式移植物会被吸收，且无法保持其原始形状。
