Holland V A, Cagle P T, Windsor N T, Noon G P, Greenberg S D, Lawrence E C
Rockwell-McKelvey Pulmonary Immunology Laboratory, Baylor College of Medicine, Houston, Texas.
Transplantation. 1990 Dec;50(6):955-9. doi: 10.1097/00007890-199012000-00011.
The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolotis obliterans following heart-lung transplantation.
心肺移植的长期成功受到闭塞性细支气管炎发展的限制，闭塞性细支气管炎可能是慢性肺移植排斥反应的一种形式。在本研究中，我们通过免疫组织化学染色对一名心肺移植患者闭塞性细支气管炎病变中浸润的淋巴细胞进行了特征分析。优势细胞表达CD8（假定的细胞毒性/抑制性）标志物这一发现支持了以下观点，即慢性排斥反应至少是心肺移植后闭塞性细支气管炎发生的一种机制。
