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我何时能知道自己痊愈了?使用条件估计为癌症生存前景提供更好的信息。

When do I know I am cured? Using conditional estimates to provide better information about cancer survival prospects.

机构信息

Viertel Centre for Research in Cancer Control, Cancer Council Queensland, Brisbane, QLD, Australia.

出版信息

Med J Aust. 2011 Jan 17;194(2):73-7. doi: 10.5694/j.1326-5377.2011.tb04171.x.

DOI:10.5694/j.1326-5377.2011.tb04171.x
PMID:21241220
Abstract

OBJECTIVE

To report the latest conditional survival estimates for patients with cancer in Queensland, Australia.

DESIGN, SETTING AND PARTICIPANTS: Descriptive study of state-wide population-based data from the Queensland Cancer Registry on patients aged 15-89 years who were diagnosed with invasive cancer between 1982 and 2007.

MAIN OUTCOME MEASURE

Conditional 5-year relative survival for the 13 most common types of invasive cancer, and all cancers combined.

RESULTS

The prognosis for patients with cancer generally improves with each additional year that they survive. A significant excess in mortality compared with the general population ceases to occur within 10 years after diagnosis for survivors of stomach, colorectal, cervical and thyroid cancer and melanoma, with these groups having a conditional 5-year relative survival of at least 95% after 10 years. For the remaining cancers we studied (pancreatic, lung, breast, prostate, kidney, and bladder cancer, non-Hodgkin lymphoma, and leukaemia), conditional 5-year relative survival estimates (at 10 years after diagnosis) ranged from 82% to 94%, suggesting that patients in these cohorts continue to have poorer survival compared with the age-matched general population.

CONCLUSIONS

Estimates of conditional survival have the potential to provide useful information for cancer clinicians, patients and their carers as they are confronted by personal and surveillance-related decisions. This knowledge may be effective in building realistic hope and helping people manage uncertainty about the future. We suggest that measures of conditional survival be incorporated into routine statistical reporting in Australia.

摘要

目的

报告澳大利亚昆士兰州癌症患者的最新条件生存估计。

设计、设置和参与者:对昆士兰癌症登记处的全州人群数据进行描述性研究,这些数据来自于 1982 年至 2007 年间诊断为侵袭性癌症的 15-89 岁患者。

主要观察结果

13 种最常见的侵袭性癌症和所有癌症的 5 年条件相对生存率。

结果

癌症患者的预后通常随着存活时间的增加而改善。与普通人群相比,胃癌、结直肠癌、宫颈癌和甲状腺癌以及黑色素瘤患者在诊断后 10 年内死亡率显著升高,这些组在 10 年后的 5 年条件相对生存率至少为 95%。对于我们研究的其余癌症(胰腺癌、肺癌、乳腺癌、前列腺癌、肾癌和膀胱癌、非霍奇金淋巴瘤和白血病),5 年条件相对生存率(诊断后 10 年)在 82%至 94%之间,表明这些队列中的患者与年龄匹配的普通人群相比,生存状况仍较差。

结论

条件生存估计有可能为癌症临床医生、患者及其护理人员提供有用的信息,因为他们面临个人和监测相关的决策。这种知识可能有助于建立现实的希望,并帮助人们管理对未来的不确定性。我们建议在澳大利亚的常规统计报告中纳入条件生存的衡量标准。

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