PANP 是一种新型的 O-糖基化 PILRα 配体，在神经组织中表达。
PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.
机构信息
Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
出版信息
Biochem Biophys Res Commun. 2011 Feb 18;405(3):428-33. doi: 10.1016/j.bbrc.2011.01.047. Epub 2011 Jan 15.
Abstract
PILRα is an immune inhibitory receptor possessing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain enabling it to deliver inhibitory signals. Binding of PILRα to its ligand CD99 is involved in immune regulation; however, whether there are other PILRα ligands in addition to CD99 is not known. Here, we report that a novel molecule, PILR-associating neural protein (PANP), acts as an additional ligand for PILRα. Transcription of PANP was mainly observed in neural tissues. PILRα-Ig fusion protein bound cells transfected with PANP and the transfectants stimulated PILRα reporter cells. Specific O-glycan structures on PANP were found to be required for PILR recognition of this ligand. These results suggest that PANP is involved in immune regulation as a ligand of the PILRα.
摘要
PILRα 是一种免疫抑制受体，其胞质域中具有免疫受体酪氨酸抑制基序 (ITIM)，使其能够传递抑制信号。PILRα 与其配体 CD99 的结合参与免疫调节；然而，除了 CD99 之外，PILRα 是否还有其他配体尚不清楚。在这里，我们报告了一种新的分子，PILR 相关神经蛋白 (PANP)，作为 PILRα 的附加配体。PANP 的转录主要在神经组织中观察到。PILRα-Ig 融合蛋白与转染 PANP 的细胞结合，并且转染子刺激 PILRα 报告细胞。发现 PANP 上的特定 O-聚糖结构是 PILR 识别该配体所必需的。这些结果表明，PANP 作为 PILRα 的配体参与免疫调节。
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